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The practice and study of medicine in Persia has a long and prolific history. The Iranian academic centers like Gundeshapur University (3rd century AD) were a breeding ground for the union among great scientists from different civilizations. These centers successfully followed their predecessors’ theories and greatly extended their scientific research through history.

In recent years, some experimental studies have indeed evaluated medieval Iranian medical remedies using modern scientific methods. These studies raised the possibility of revival of traditional treatments on the basis of evidence-based medicine.

Pre-Islamic

The medical history of ancient Persia can be divided into three distinct periods. The sixth book of Zend-Avesta contains some of the earliest records of history of ancient Iranian medicine. The Vendidad in fact devotes most of the last chapters to medicine. The Vendidad, one of the surviving texts of the Zend-Avesta, distinguishes three kinds of medicine: medicine by the knife (surgery), medicine by herbs, and medicine by divine words; and the best medicine was, according to the Vendidad, healing by divine words:

“Of all the healers O Spitama Zarathustra, namely those who heal with the knife, with herbs, and with sacred incantations, the last one is the most potent as he heals from the very source of diseases.” — Ardibesht Yasht

Although the Avesta mentions several notable physicians, the most notable--Mani, Roozbeh, and Bozorgmehr—were to emerge later. The second epoch covers the era of what is known as Pahlavi literature, where the entire subject of medicine was systematically treated in an interesting tractate incorporated in the encyclopedic work of Dinkart, which listed in altered form some 4333 diseases.

The third era begins with the Achaemenid dynasty, and covers the period of Darius I of Persia, whose interest in medicine was said to be so great that he re-established the school of medicine in Sais, Egypt, which previously had been destroyed, restoring its books and equipment. The first teaching hospital was the Academy of Gundishapur in the Persian Empire. Some experts go so far as to claim that, "to a very large extent, the credit for the whole hospital system must be given to Persia". According to the Vendidad, physicians, to prove proficiency, had to cure three patients from the followers of Divyasnan; if they failed, they could not practice medicine. At first glance, this recommendation may appear discriminant and based on human experimentation. But some authors have construed this to mean that, from the beginning, physicians were taught to remove the mental barrier and to treat adversaries as well as friends. Interestingly, physician’s fee for service was based on the patient’s income.

The Iranian science was interrupted by the Arab invasion (630 A.D.). Many schools, universities, and libraries were destroyed, books burned, and scholars killed. Nevertheless, the science of Persia resurfaced during the Islamic period. To save the books from Arab carnage, many Pahlavi scripts were translated into the Arabic, and Iran produced physicians and scientists such as Abū ʿAlī al-Ḥusayn ibn ʿAbd Allāh ibn Sīnā and Muhammad ibn Zakariya al-Razi as well as mathematicians such as Kharazmi and Omar Khayyám. They collected and systematically expanded the Greek, Indian, and Persian ancient medical heritage and made further discoveries.

Medieval Islamic Period

One of the main roles played by medieval Iranian scholars in the scientific field was the conservation, consolidation, coordination and development of ideas and knowledge in ancient civilizations. Some Iranian Hakim (practitioners) such as Muhammad ibn Zakariya ar-Razi, known to the West as Rhazes, and Ibn Sina, better known as Avicenna, were not only responsible for accumulating all the existing information on medicine of the time, but adding to this knowledge by their own astute observations, experimentation and skills. "Qanoon fel teb of Avicenna" ("The Canon") and "Kitab al-hawi of Razi" ("Continens") were among the central texts in Western medical education from the 13th to the 18th centuries. In the 14th century, the Persian language medical work Tashrih al-badan (Anatomy of the body), by Mansur ibn Ilyas (c. 1390), contained comprehensive diagrams of the body's structural, nervous and circulatory systems.